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eBook details

• Title: Serologic Markers in Inflammatory Bowel Disease.
• Author : Clinical Chemistry
• Release Date : January 01, 2006
• Genre: Chemistry,Books,Science & Nature,
• Pages : * pages
• Size : 208 KB

Description

Inflammatory bowel disease (IBD) (1) embodies a spectrum of disorders that affect the gastrointestinal tract, the 2 major entities being Crohn disease (CD) and ulcerative colitis (UC). IBD is a lifelong disease involving mostly young people, often in a severe way. Although the etiology of IBD is unknown at present, it is believed to be an immunologically mediated disease in a genetically susceptible host. The picture that emerges is that IBD results from an aberrant immune response and loss of tolerance to the normal intestinal flora, leading to chronic inflammation of the gut. This idea is supported by the occurrence of antibodies directed to microbial antigens (see below) and by the identification of CARD15 as a gene conferring susceptibility to CD (1). CARD15 plays a role in the recognition of bacterial structures and in the subsequent defense against these bacteria through nuclear factor-[kappa]B. Several (auto)antibodies have been described in IBD. The 2 most intensively studied antibodies are autoantibodies to neutrophils [atypical perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCAs)] and anti-Saccharomyces cerevisiae antibodies (ASCAs). This review summarizes the current knowledge about the putative clinical value of these 2 antibodies in IBD. Pancreatic antibodies and newly identified anti-microbial antibodies (anti-outer membrane porin C, anti-I2, and anti-flagellin) are also reviewed.

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